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  This limitation is just restricted by the way that twelve tablets, each containing 325 milligrams of APAP, puts the patient right underneath the 24-hour FDA limit of 4,000 mg of APAP. Some extraordinarily intensified items are regularly given to ongoing torment patients in dosages of up to 180 mg of hydrocodone each day.  Side effects of  hydrocodone  overdosage incorporate respiratory sadness, outrageous sleepiness, extreme lethargies, daze, cold as well as damp skin, now and again bradycardia, and hypotension. An extreme excess may include circulatory breakdown heart failure as well as death. The presence of acetaminophen in hydrocodone -containing things blocks numerous medicine customers from taking over the top aggregates. Regardless, a couple of customers will get around this by isolating a piece of the acetaminophen using hot/cold water, taking advantage of the water-dissolvable segment of the medicine.  It's everything except remarkable for addicts to have liver issues fr